Document Type : Research articles
Authors
- Reza Alizadeh-Navaei 1
- Majid Saeedi 2
- Reza Valadan 3
- Fatemeh Roozbeh 1
- Omolbanin Amjadi 1
- Ehsan Zaboli 1
- Mahmood Moosazadeh 4
- Hossein Ranjbaran 5
- Zinab Qazizadeh 6
- Ali Akbari-Malekshah 1
- Touraj Assadi 7
- Versa Omrani-Nava 1
- Akbar Hedayatizadeh-Omran 1
1 Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3 Department of Immunology, Mazandaran University of Medical Sciences, Sari, Iran
4 Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
5 Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
6 Population-Based Cancer Registry, Mazandaran University of Medical Sciences, Sari, Iran
7 Department of Emergency Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Abstract
Background: Coronavirus is a single-stranded RNA virus, causing an epidemic of pneumonia and acute respiratory distress syn- drome (ARDS) worldwide in late 2019.
Objectives: In addition to the clinical symptoms, laboratory diagnosis can greatly help diagnose the diseases; therefore, this study aimed to analyze laboratory parameters in patients with COVID-19.
Methods: In this cross-sectional study, the laboratory data of 2563 patients with COVID-19 admitted to hospitals affiliated with Mazandaran University of Medical Sciences were extracted from hospital information systems (HIS). The data were recorded on Excel and analyzed through t-test, chi-squared, and Fishers exact tests in SPSS 19 at the significance level of P < 0.05.
Results: Out of 2563 patients with a mean age of 55.1 ± 16.7 years, 1409 (55%) were male, and 1154 (45%) were female with a mean age of 55.7 ± 16.8, and 54.3 ± 16.6 years, respectively. As the most frequent clinical findings, ESR, CRP, and LDH were increased by 83.5%, 71%, and 69.3% of the patients, respectively. Other research findings included lymphopenia, disturbed INR, abnormal SGOT, abnormal alkaline phosphatase (ALP), and increased lactate dehydrogenase (LDH), which were significantly higher in men than in women and was different between age groups.
Conclusions: Conducting simple, convenient, and inexpensive laboratory tests can be helpful in the diagnosis of COVID-19.
Keywords
- Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020;382(10):929-36. doi: 10.1056/NEJMoa2001191. [PubMed: 32004427]. [PubMed Central: PMC7092802].
- Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med. 2020. doi: 10.1515/cclm-2020-0240.
- Sohrabi C, Alsafi Z, O'Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-6. doi: 10.1016/j.ijsu.2020.02.034. [PubMed: 32112977]. [PubMed Central: PMC7105032].
- Milek J, Blicharz-Domanska K. Coronaviruses in Avian Species - Review with Focus on Epidemiology and Diagnosis in Wild Birds. J Vet Res. 2018;62(3):249-55. doi: 10.2478/jvetres-2018-0035. [PubMed: 30584600]. [PubMed Central: PMC6296008].
- Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020. doi: 10.1001/jama.2020.1585. [PubMed: 32031570]. [PubMed Central: PMC7042881].
- Huang C, Wang Y, Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
- Mardani R, Ahmadi Vasmehjani A. Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. Archives of Academic EmergencyMedicine. 2020;8(1). e43. [PubMed Central: PMC7130449].
- Arentz M, Yim E. Characteristics and Outcomes of 21 Critically Ill PatientsWith COVID-19 inWashington State. American Medical Association. 2020. doi: 10.1001/jama.2020.4326.
- Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63(3):364–374. doi: 10.1007/s11427-020-1643-8.
- Wu J, Liu J. Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study. Clin Infect Dis. 2020;Published by Oxford University Press for the Infectious Diseases Society of America. doi: 10.1093/cid/ciaa199.
- W. Guan Z. Clinical Characteristics of Coronavirus Disease 2019 in China. The new england journal of medicine. 2020. doi: 10.1056/NEJMoa2002032.
- Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020. doi: 10.1515/cclm-2020-0198.
- Xu XW, Wu X, Jiang XG, Xu KJ, Ying LJ, Ma CL. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. Br Med J. 2020;368:m606. doi: 10.1136/bmj.m606.
- Ng Y, Li Z. Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore — January 2–February 29, 2020. Morbidity and Mortality Weekly Report. 2020;69(11):307-11. doi: 10.15585/mmwr.mm6911e1.
- Jin-jin Zhang XD. Clinical characteristics of 140 patients infected with SARSCoV-2 in Wuhan, China. Allergy. 2020:1-12. doi: 10.1111/all.14238.
- Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. doi: 10.1016/S0140-6736(20)30211-7.
- Chaolin H, Yeming W. Clinical features of patients infected with 2019 novel coronavirus in Wuhan
', './data/ircmj/coversheet/cover_en.jpg'))