Document Type : Research articles
Authors
- Mehmet Sabri Balik 1
- Levent Tumkaya 2
- Tolga Mercantepe 2
- Adnan Yilmaz 3
- Gulsah Balik 4
- Atilla Topcu 5
- Zihni Yazici 6
1 Department of Orthopedic and Traumatology, Recep Tayyip Erdogan University, Rize, Turkey
2 Department of Histology and Embryology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
3 Department of Medical Biochemistry, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
4 Department of Obstetrics and Gynecology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
5 Department of Medical Pharmacology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
6 Department of Microbiology, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey
Abstract
Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. In skeletal muscles, the toxic effect manifests as atrophy. Objectives: The tea grape extract (TGE) is a sort of whortleberry that has various physiological effects including prevention of chem- ically induced cellular insults. Therefore, we examined if the TGE has a protective effect against the Cis induced skeletal muscle atrophy. Methods: Female Sprague-Dawley rats were used in this animal experimental study. Rats were allocated into different study groups, each with eight members. The groups comprised control, solvent control, 200 mg TGE, Cis, Cis + 100 mg TGE, and Cis + 200 mg TGE. Results: The mean fiber area of the skeletal muscle (MFASM) decreased significantly in the Cis group in comparison to the control
group (P = 0.01). MFASM showed similarities between the Cis + TGE 200 and control groups (P > 0.05, P = 0.418). Similarities were also observed for MFASM between the Cis + 100 mg TGE and Cis + 200 mg TGE groups (P > 0.05, P = 0.891). The mean serum calcium level in the Cis group (10.26 ± 0.29) was significantly higher in TGE 100 (9.13 ± 0.11) and TGE 200 groups (9.21 ± 0.13). Conclusions: It is concluded that the tea grape extract has a protective effect on Cis-induced toxicity of the skeletal muscles.
Keywords
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