Document Type : Research articles
Authors
1 Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
2 Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran
3 Community Based Participatory Research Center, Iranian Institute for Reduction of High-Risk Behaviors, Center for Academic and Health Policy, Tehran University of Medical Sciences, Tehran, Iran
4 Pain Research Center, Rasoul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
Abstract
Background: Postoperative pain is a major complication in patients undergoing eye surgery. N-methyl-D-aspartate (NMDA) recep- tor antagonists are widely used to manage postoperative pains. Dextromethorphan, as an NMDA antagonist, is commonly used as an oral drug. Objectives: This study was conducted to evaluate the effect of Dextromethorphan on post-operation pain and sedative effect in comparison to placebo. Methods: A double-blinded, placebo-controlled, randomized clinical trial, upon 60 patients undergoing vitrectomy surgery was
done. Thirty patients received 30 mg oral Dextromethorphan before the operation, and 30 patients received a placebo. Post- operation pain and sedation were evaluated after zero, one, two, and six hours. Results: Post-operation pain was significantly lower in patients who received Dextromethorphan at zero, one, and two hours after
operation (P < 0.001); however, not at six hours after operation (P = 0.11). Sedative effect was higher in the Dextromethorphan group at zero (P = 0.03) and one hour (P = 0.01) after operation. Conclusions: Prescribing oral Dextromethorphan before a vitrectomy surgery could reduce postoperative pain. It also has postop-
erative sedation effects.
Keywords
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